Director/PDMR Shareholding

GlaxoSmithKline PLC
13 April 2006

   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons

I give below details of changes in the interests of Directors, Persons
Discharging Managerial Responsibility or Connected Persons in the Ordinary
Shares of GlaxoSmithKline plc in respect of the under-mentioned persons arising
from the purchase of Ordinary Shares at a price of £14.93 per Ordinary Share on
11 April 2006 through the Company's ShareReward Plan ("the Plan") which the
under-mentioned persons entered on 5 October 2001:

Mr R Bondy                       Acquisition of 8 Ordinary Shares under the 
                                 partnership element of the Plan (personal 
                                 contribution)

                                 Acquisition of 8 Ordinary Shares under the 
                                 matching element of the Plan 
                                 (Company contribution)

Mr J S Heslop                    Acquisition of 8 Ordinary Shares under the 
                                 partnership element of the Plan 
                                 (personal contribution)

                                 Acquisition of 8 Ordinary Shares under the 
                                 matching element of the Plan
                                 (Company contribution)

Mr A P Witty                     Acquisition of 8 Ordinary Shares under the 
                                 partnership element of the Plan 
                                 (personal contribution)

                                 Acquisition of 8 Ordinary Shares under the 
                                 matching element of the Plan
                                 (Company contribution)

Mrs J V Younger                  Acquisition of 8 Ordinary Shares under the 
                                 partnership element of the Plan
                                 (personal contribution)

                                 Acquisition of 8 Ordinary Shares under the 
                                 matching element of the Plan
                                 (Company contribution)

The Company and the above-mentioned persons were advised of this information on
12 April 2006.

This notification relates to a transaction notified in accordance with
Disclosure Rules 3.1.4R(1)(a) and 3.1.4R(1)(b).

S M Bicknell
Company Secretary

13 April 2006


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