Director/PDMR Shareholding

GlaxoSmithKline PLC
19 December 2005



   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons

I give below details of changes in the interests of Directors, Persons
Discharging Managerial Responsibility or Connected Persons in the Ordinary
Shares of GlaxoSmithKline plc.

                         
   14 December 2005      Abacus (GSK) Trustees Limited, as trustee of the
                         GlaxoSmithKline Employee Trust, ("the GSK Trust"), 
                         sold 3,250 Ordinary Shares in the Company on behalf of 
                         participants in the GlaxoSmithKline Restricted Share 
                         Plan at a price of £14.6026 per share.


   14 December 2005      Abacus (GSK) Trustees Limited, as trustee of the 
                         GSK Trust, transferred 16,484 Ordinary Shares in the 
                         Company to participants in the GlaxoSmithKline 
                         Restricted Share Plan.


   16 December 2005      Abacus (GSK) Trustees Limited, as trustee of the 
                         GSK Trust, transferred 9,300 Ordinary Shares in the 
                         Company to participants in the SmithKline Beecham 
                         Employee Share Option Plan 1991.


The Company was advised of these transactions on 19 December 2005.

The GSK Trust is a discretionary trust of which all employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. Three of the Company's directors, Dr J-P Garnier, Dr T Yamada and
Mr J S Heslop are therefore interested in the shares held in the GSK Trust from
time to time in the same way as other employees or former employees of
GlaxoSmithKline plc and its subsidiaries.

This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1.4R(1)(b).


S M Bicknell
Company Secretary


19 December 2005


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