Director/PDMR Shareholding

GlaxoSmithKline PLC
15 December 2005


I give below details of changes in the interests of Directors, Persons
Discharging Managerial Responsibility or Connected Persons in the Ordinary
Shares of GlaxoSmithKline plc.
                         
                         
   12 December 2005      Abacus Corporate Trustee Limited, as trustee of the
                         GlaxoSmithKline (US) Trust, ("the GSK US Trust"), sold 
                         1,972 ADR Shares in the Company to participants in the
                         GlaxoSmithKline Restricted Share Plan at a price of 
                         $50.99 per ADR share.

                         Abacus Corporate Trustee Limited, as trustee of the 
                         GSK US Trust, transferred 4,093 ADR Shares to 
                         participants in the GlaxoSmithKline Restricted Share 
                         Plan.

The Company was advised of these transactions on 15 December 2005.

The GSK US Trust is a grantor trust of which all employees or former employees
of SmithKline Beecham Corporation and its subsidiaries are potential
beneficiaries. Two of the Company's directors, Dr J-P Garnier and Dr T Yamada
are therefore interested in the shares held in the GSK US Trust from time to
time in the same way as other employees or former employees of SmithKline
Beecham Corporation and its subsidiaries.

This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1.4R(1)(b).

S M Bicknell
Company Secretary


15 December 2005

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