Director/PDMR Shareholding

GlaxoSmithKline PLC
04 April 2006





   Notification of Transactions of Directors, Persons Discharging Managerial
                      Responsibility or Connected Persons


I give below details of changes in the interests of Directors, Persons
Discharging Managerial Responsibility or Connected Persons in the Ordinary
Shares of GlaxoSmithKline plc.
                    

   28 March 2006         The Administrators of the SmithKline Beecham 
                         Employee Benefit Trust ("the Trust") notified 
                         the Company on 3 April 2006 that 1005 Ordinary 
                         shares had been sold on 28 March 2006 on behalf 
                         of participants in the SmithKline Beecham Bonus 
                         Investment Plan at a price of £15.13.

                         The Trust also notified the Company on 3 April 
                         2006 that 1193 Ordinary shares had been 
                         transferred on 28 March 2006 from the Trust to 
                         participants in the SmithKline Beecham Bonus 
                         Investment Plan.


   28 March 2006


The Trust is a discretionary fund of which all non US employees or former
employees of GlaxoSmithKline plc and its subsidiaries are potential
beneficiaries. One of the Company's directors, Mr J Heslop is therefore
interested in the shares held in the fund from time to time in the same way as
other non US employees or former employees of GlaxoSmithKline plc and its
subsidiaries.



This notification relates to a transaction notified in accordance with
Disclosure Rule 3.1.4R(1)(b).


S M Bicknell
Company Secretary
4 April 2006






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