Holding(s) in Company

Advance Focus Fund Limited has received the following notification of
a major interest in its shares.


TR-1(i): NOTIFICATION OF MAJOR INTERESTS IN SHARES

1. Identity of the issuer or the underlying issuer of existing shares
to which voting rights are attached (ii):
    Advance Focus Fund Limited

2. Reason for the notification (please state Yes/No): (    )

An acquisition or disposal of voting rights: (No )

An acquisition or disposal of financial instruments which may result
in the acquisition of shares already issued to which voting rights
are attached: (No  )

An event changing the breakdown of voting rights: (No  )

Other (please specify) : Compliance with DTR Transitional Provision 7
(Yes)

3. Full name of person(s) subject to the notification obligation
(iii):
QVT Financial LP

4. Full name of shareholder(s) (if different from 3.) (iv):
QVT Fund LP

5. Date of the transaction (and date on which the threshold is
crossed or  reached if different) (v):
N/a - Disclosure made pursuant to DTR - TP 7

6. Date on which issuer notified:
19 March 2007

7. Threshold(s) that is/are crossed or reached:
     15%

8. Notified details:



A: Voting rights attached to shares


Class/type of shares if possible Situation previous to the Triggering
using the ISIN CODE                        transaction (vi)
Redeemable                       Number of shares   Number of voting
Preference                                          Rights (viii)
Shares




Resulting situation after the triggering transaction (vii)


Class/type of shares if Number of Number of voting    % of voting
possible using the ISIN shares    rights (ix)         rights
CODE
Redeemable              Direct    Direct (x) Indirect Direct Indirect
Preference                                   (xi)
Shares                  4,747,671 4,747,671           18.88% -
                                             -



B: Financial Instruments
Resulting situation after the triggering transaction (xii)


Type of    Expiration  Exercise/Conversion Number of voting    % of
financial  Date (xiii) Period/ Date (xiv)  rights that may be  voting
instrument                                 acquired if the     rights
                                           instrument is
                                           exercised/
                                           converted.




Total (A+B)

Number of voting rights % of voting rights
4,747,761               18.88%


9. Chain of controlled undertakings through which the voting rights
and/or the financial instruments are effectively held, if applicable
(xv):
.......

Proxy Voting:

10. Name of the proxy holder:
.......

11. Number of voting rights proxy holder will cease to hold:
.......

12. Date on which proxy holder will cease to hold voting rights:
.......
13. Additional information:


14. Contact name:
Lars Bader

15. Contact telephone number:
[phone]



The person making this announcement on behalf of Advance Focus Fund
Limited is as follows;

Anthony Lee - tel: [phone]

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