Holding(s) in Company

Advance Focus Fund Limited has received the following notification of
a major interest in its shares.


TR-1(i): NOTIFICATION OF MAJOR INTERESTS IN SHARES

1. Identity of the issuer or the underlying issuer of existing shares
to which voting rights are attached (ii):
    Advance Focus Fund Limited

2. Reason for the notification (please state Yes/No): (    )

An acquisition or disposal of voting rights: (No )

An acquisition or disposal of financial instruments which may result
in the acquisition of shares already issued to which voting rights
are attached: (No  )

An event changing the breakdown of voting rights: (No  )

Other (please specify) : Notification of holding at 20 Jan 2007 (Yes)

3. Full name of person(s) subject to the notification obligation
(iii):
JPMorgan Chase & Co.

4. Full name of shareholder(s) (if different from 3.) (iv):
JPMorgan Asset Management (UK) Limited

5. Date of the transaction (and date on which the threshold is
crossed or  reached if different) (v):
N/a

6. Date on which issuer notified:
6 February 2007

7. Threshold(s) that is/are crossed or reached:
     5%

8. Notified details:



A: Voting rights attached to shares


Class/type of shares if possible Situation previous to the Triggering
using the ISIN CODE                        transaction (vi)
Advance Focus Fund Limited (ISIN Number of shares   Number of voting
GB0031991879)                    N/a                Rights (viii)
                                                    N/a




Resulting situation after the triggering transaction (vii)


Class/type of shares if    Number of Number of voting % of voting
possible using the ISIN    shares    rights (ix)      rights
CODE
Advance Focus Fund Limited Direct    Direct Indirect  Direct Indirect
(ISIN GB0031991879)                  (x)    (xi)
                           -                          -      7.45
                                     -      2,000,000



B: Financial Instruments
Resulting situation after the triggering transaction (xii)


Type of    Expiration  Exercise/Conversion Number of voting    % of
financial  Date (xiii) Period/ Date (xiv)  rights that may be  voting
instrument                                 acquired if the     rights
                                           instrument is
                                           exercised/
                                           converted.




Total (A+B)

Number of voting rights % of voting rights
2,000,000               7.45


9. Chain of controlled undertakings through which the voting rights
and/or the financial instruments are effectively held, if applicable
(xv):
.......

Total disclosable holding for JPMorgan Chase & Co.: 2,000,000 voting
rights (7.45%)

Holdings by controlled undertakings of JPMorgan Chase & Co. are as
follows:

JPMorgan Asset Management (UK) Limited: 2,000,000 voting rights
(7.45%)


Proxy Voting:

10. Name of the proxy holder:
.......

11. Number of voting rights proxy holder will cease to hold:
.......

12. Date on which proxy holder will cease to hold voting rights:
.......
13. Additional information:
 This is notification of disclosable holding as at 20 January 2007

14. Contact name:
Katie Green

15. Contact telephone number:
020 7777 3028



The person making this announcement on behalf of Advance Focus Fund
Limited is as follows;

Anthony Lee - tel: [phone]

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