Launch of Consultancy Service

e-Therapeutics plc 06 May 2008 Press Release 6th May 2008 e-Therapeutics plc ('e-Therapeutics' or 'the Company') Launch of a Consultancy Service for Drug Discovery and Development e-Therapeutics plc (AIM: ETX), the systems biology drug discovery company, today announces the launch of its new consultancy service. The service will enable pharmaceutical and biotechnology companies to use the Company's proprietary and patented in silico technology to analyse their drug compounds for indication, efficacy and toxicity. e-Therapeutics' in silico technology accurately predicts the holistic effects of compounds within the body and enables rapid and accurate efficacy and toxicity identifications at a lower cost than traditional discovery methods. e-Therapeutics has already used its technology in a number of projects with companies including GlaxoSmithKline plc, Mylan Laboratories Inc, Chakra Biotech Pte Ltd and Cambridge Laboratories Ltd. Malcolm Young, CEO of e-Therapeutics, commented: 'Our technology rapidly predicts how new medicines will interact with cells and other drugs in the body. This maximises the probability of identifying drug candidates with the desirable combination of high efficacy and low toxicity. Our approach is cost-effective and will permit partners to de-risk investment decisions before they commit the substantial sums required to bring a new drug through clinical development. Older, conventional approaches have not proven accurate enough to produce safe and effective drugs, evidenced by the recognised industry problem of an unsustainable attrition rate.' The Company is offering a range of unique services for the evaluation of candidate drugs, these include: • determining mode of action; • predicting efficacy; • identifying appropriate positioning against competing drugs; • identifying potential toxicity, safety and tolerance problems; and • characterising possible drug interactions. Clients using these services are able to make more informed judgements regarding the value of their candidates before committing further investment. e-Therapeutics' reports also provide clarity and additional information to support patent applications. In addition to these services, e-Therapeutics is offering its unique capabilities to collaborate with partners in a variety of ways, including establishing alternative therapeutic uses for compounds, and analysis of entire compound libraries. John Cordiner, Commercial and Finance Director, commented: 'Our consulting and contract research projects have up to now effectively sold themselves. We now have a substantial track record of delivering significant value to our partners in these projects, and so now is the time to make our capabilities more widely known to other discovery and development programmes, so that they can also benefit.' Drugs are active through multiple interactions with many proteins and genes. The conventional approach of focusing on single drug targets has led to incorrect conclusions on efficacy and safety and has proven hugely expensive for a number of companies as candidate drugs fail in late-stage development. The single target approach also makes it very difficult to address multi-factorial disease. e-Therapeutics' technology has been carefully validated by back-testing. Using only internal data resources and analyses, the technology has successfully identified the known drugs for selected specific diseases, and also all the secondary effects of other drugs in these diseases that have been reported in the literature. For example, in a sweep across 97 bacterial pathogens, the e-Therapeutics technology not only successfully identified all currently known antibiotic classes, including 103 known and secondary effect antibiotics, but also found several entirely novel antibiotic candidates that have since demonstrated positive effects in the laboratory. - ENDS - For further information: e-Therapeutics plc www.etherapeutics.co.uk Malcolm Young +44 (0)191 233 1317 malcolm@etherapeutics.co.uk Nominated Advisor: WH Ireland Richard Lindley +44 (0)113 394 6628 richard.lindley@wh-ireland.co.uk Broker: Cornhill Asset Management Tom Whitehead +44 (0) 207 645 8327 tomw@cornhillassetmanagement.com Andrew Houchin +44 (0) 207 743 6468 andrewh@cornhillassetmanagement.com Media enquiries: Abchurch www.abchurch-group.com Heather Salmond +44 (0) 207 398 7711 Heather.salmond@abchurch-group.com Stephanie Cuthbert +44 (0) 207 398 7718 stephanie.cuthbert@abchurch-group.com Notes to Editors e-Therapeutics plc is a systems biology drug discovery company. It has developed proprietary computational systems to swiftly and accurately analyse and predict how medicines interact with cells in the body. This optimises the probability of identifying drug candidates with desirable efficacy and low toxicity. The Company applies its novel, systematic approach to three areas of activity: • Discovery of new drugs; • Discovering novel uses for existing drugs; and • Analysis of the interactions between different drugs. Amongst e-Therapeutics' pipeline of compounds in development are novel antibiotics that have been shown to kill the 'superbug' MRSA, and a novel cancer chemotherapy that has been shown to kill malignant cells at safe doses in a very short time. Other candidate therapies in development are targeted at atherosclerosis, asthma and depression. The Company is currently in negotiations with a number of pharmaceutical companies, and is progressing the preclinical and clinical development of these products. For further information on e-Therapeutics visit www.etherapeutics.co.uk. This information is provided by RNS The company news service from the London Stock Exchange
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