AGM Statement

Deltex Medical Group PLC 03 May 2007 Deltex Medical Group plc ('Deltex Medical' / 'Company') Results of Annual General Meeting/Trading Update 3 May 2007: Deltex Medical Group plc ('Deltex Medical' or the 'Company'), the UK's leading haemodynamic monitoring company today held its Annual General Meeting. All resolutions put to shareholders at the meeting were passed. The following is the text of a statement made at the meeting by the Company's chairman, Nigel Keen. 'Progress in the first four months of 2007 has continued to reflect the growing interest from anaesthetists, surgeons and hospital managers to establish use of Deltex Medical's CardioQ(TM) oesophageal Doppler monitor (ODM) as a standard of care in the treatment of patients undergoing major surgery or in intensive care. Sales in both our major direct markets, the UK and the USA, were ahead of last year in both the first quarter and in April. It is particularly encouraging that there have been early but clear signs that the growth rate from our US business has increased. Sales through our distributor partners into International markets are also growing satisfactorily. As expected, growth in all our markets is quickest in the operating theatre where ODM is the only intra-operative haemodynamic monitoring technology demonstrated in randomised controlled trials to reduce post-operative complications and consequently shorten lengths of hospital stay. Fast-track or enhanced recovery surgical programmes that aim to incorporate evidence-based medicine into clearly defined treatment protocols are being established in continental Europe, the UK and the USA. The CardioQ has a central role to play in delivering the goals of these programmes. In April, University College London Hospital (UCLH) announced that it had embarked on the implementation of its Enhanced Surgical Treatment and Recovery Programme (ESTREP). This programme, initially targeted at patients undergoing bowel surgery, is planned to become standard clinical practice for all patients undergoing major surgery at UCLH. Use of the CardioQ as a standard of care for Targeted Volume Management is a key component in this programme. Other influential teaching hospitals, as well as a number of District General Hospitals, throughout the UK are at various stages of planning or actual implementation of similar programmes, again with an initial focus mainly on bowel surgery. It is increasingly well recognised that adoption of the CardioQ is an essential step in the successful introduction of these programmes. The aim of these new surgical care programmes is to improve outcomes and reduce length of hospital stay for all patients undergoing major surgery, and establish new standards of care that are centred on evidence-based best practice. In February in the USA the Centers for Medicare & Medicaid Services (CMS), the body responsible for healthcare provision to the elderly and poor, published a proposed recommendation that ODM be covered for reimbursement when used in the Medicare and Medicaid patient population. Insurers and other healthcare payment organisations generally follow CMS's lead and are likely to provide coverage in due course. A final decision is due to be published within the next month. While coverage does not absolutely guarantee reimbursement to the physician for the time and skill required to manage patients using ODM, it is most unlikely that such reimbursement would be granted in the absence of a positive coverage determination. The CMS draft decision is a major step on the path to establishing ODM as a standard of care in the USA. The CMS decision was based on a health technology assessment commissioned from the US Government Agency for Healthcare Research and Quality (AHRQ). This health technology assessment undertook a detailed and rigorous review of the published literature concerning ODM and the unique body of randomised, controlled clinical trial data associated with ODM technology. The assessment concluded that 'Doppler-guided fluid replacement during surgery leads to a clinically significant reduction in major complications'; that 'Doppler-guided fluid replacement during surgery leads to a clinically significant reduction in the total number of complications'; and that 'Doppler-monitored fluid replacement leads to a reduction in hospital stay'. AHRQ assessed the evidence for these conclusions to be strong - in this context, 'strong' means that 'it is highly unlikely that new evidence will lead to a change in this conclusion'. Early in 2007 we reported that the US military were to embark on an evaluation of the CardioQ in wounded soldiers being treated at a combat support hospital in Iraq. We can confirm that patients have begun to be treated using ODM and that valuable information on optimal fluid therapy in this environment has already been gained. We are currently working with a number of US hospitals, including two institutions rated as among the top 10 US hospitals*, to support the implementation of routine use of the CardioQ in major surgery. These projects involve multi-disciplinary teams developing protocols to ensure consistent patient care and represent the establishment of Targeted Volume Management as a standard of care in the US. In our International business, we are seeing clear benefits from the restructuring of our trading relationships with our key European distributors in the first half of 2006. Our sales of probes to distributors are now much more closely linked to underlying usage rates in hospitals. Increased adoption of the CardioQ in many individual countries is feeding through to steady growth in our sales. In Germany, at the Charite Hospital in Berlin, doctors have been working with the CardioQ in their fast-track colorectal surgery programme and in patients undergoing spinal surgery. We are currently working with the hospital to develop and support an implementation programme for wide-scale usage in all major surgery. As well as being one of Germany's leading teaching hospitals, the Charite is also closely involved in setting the standards for intra-operative care for a leading multi-site pan-European fast-track surgery programme. Our new product development activities are centred on broadening the markets for our technology by making it more suitable for use in awake patients and outside critical care wards and operating theatres. We have passed important development milestones with both the wholly non-invasive SupraQO monitor and an enhanced oesophageal probe. The board looks forward to continued progress throughout the remainder of 2007 and beyond'. End *U.S. News & World Report list of the United States' best hospitals, as prepared by the National Opinion Research Center at the University of Chicago For further information, please contact:- Deltex Medical Group plc 01243 774 837 Nigel Keen, Chairman njk@deltexmedical.com Andy Hill, Chief Executive ahill@deltexmedical.com Ewan Phillips, Finance Director eap@deltexmedical.com Gavin Anderson & Company 020 7554 1400 Deborah Walter dwalter@gavinanderson.co.uk Robert Speed rspeed@gavinanderson.co.uk Charles Stanley Securities 020 7149 6457 Philip Davies philip.davies@csysecurities.com Russell Cook russell.cook@csysecurities.com Notes for Editors Deltex Medical manufactures and markets the CardioQ(TM) monitor, which uses disposable ultra-sound probes inserted into the oesophagus to determine the amount of blood being pumped around the body - 'circulating blood volume'. Reduced circulating blood volume is known as hypovolaemia, which leads to insufficient oxygen being delivered to the organs. This causes medical complications including peripheral and major organ failure which can lead to death. Hypovolaemia, which is akin to severe dehydration, affects virtually every patient having surgery because of the combined effects of pre-operative starvation, the impact of the anaesthetic agents and trauma from the surgery itself. Using fluids and drugs, guided by the CardioQ, to optimise the amount of circulating blood significantly reduces post-operative complications allowing patients to make a faster, more complete recovery and return home earlier. The CardioQ incorporates the Company's proprietary software and a small diameter, easy-to-use, minimally invasive, disposable oesophageal probe that is used for transmitting and receiving an ultra-sound signal. By using this technology, the CardioQ provides clinicians with the ability to haemodynamically optimise critically ill patients and those undergoing routine moderate to major surgery through the controlled administration of fluid and drugs. Haemodynamic optimisation has been scientifically proven to improve the speed and quality of patient recovery and reduce hospital stay. There are already over 1,250 CardioQs currently in use in hospitals worldwide and distribution arrangements are in place in over 30 countries. In addition, there are currently more than 90 clinical publications on the use of the CardioQ which have repeatedly:- • Validated the results of the Monitor against known standards for measuring cardiac output, demonstrating that the technology works • Proved that the CardioQ works in a wide range of surgical procedures • Demonstrated that the Company's technology provides significant health and economic benefits by helping to reduce post-operative complications and length of hospital stays by an average of 30 to 40 per cent for a wide range of patients. The SupraQ(TM) is an entirely non-invasive device which uses an ultrasound probe held at the base of the patient's neck to track the flow of blood in the aorta; it presents the same data as the CardioQ in a similar format and is used for taking snapshots or monitoring over short periods. This information is provided by RNS The company news service from the London Stock Exchange
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