Re Agreement

Cambridge Antibody Tech Group PLC 21 May 2001 01/CAT/09 FOR IMMEDIATE RELEASE 07.00 BST, 02.00 EST Monday 21 May 2001 For Further Information Contact: Cambridge Antibody Technology Square Mile Communications (Europe) Tel: +44 (0) 1763 263 233 Tel: +44 (0) 20 7601 1000 David Chiswell, CEO Kevin Smith John Aston, Finance Director Graham Herring Rowena Gardner, Head of Corporate Communications Immunex Corporation BMC Communications/The Trout Group (USA) Kris Greco (media) Tel: 001 212 477 9007 Tel: 001 206 470 4871 Brad Miles, ext 17 (media) Mark Leahy (investors) Brandon Lewis, ext.15 (investors) Tel: 001 206 389 4363 CAMBRIDGE ANTIBODY TECHNOLOGY AND IMMUNEX CORPORATION ENTER INTO NEW ALLIANCE FOR HUMAN MONOCLONAL ANTIBODY CO-DEVELOPMENT Collaboration will focus on development of novel antibody-based anti-inflammatory drugs Melbourn, UK and Seattle, WA... Cambridge Antibody Technology (LSE: CAT) and Immunex Corporation (Nasdaq: IMNX) announce a broad product development collaboration committed to the joint discovery, development, marketing and sale of human antibody-based therapeutics for autoimmune and inflammatory disorders. Under the terms of the agreement, the two companies will share equal responsibility for all research and development, and split equally any potential profits generated by product sales. Immunex will contribute two undisclosed proprietary targets, scientific and development expertise to the partnership, while CAT will contribute its proprietary human antibody phage display technology and high throughput screening capabilities to identify human antibodies. CAT will have primary responsibility for the discovery and optimisation of human antibodies specific to the Immunex targets. Immunex will be primarily responsible for additional pre-clinical evaluation, clinical trials and product commercialisation. Dr. David Chiswell, CEO of CAT, said 'We are extremely pleased to be expanding our relationship with Immunex for the custom design and development of human antibody drugs. It is a further demonstration of CAT's commitment to share in the risks and rewards of antibody product development and to build a drug pipeline serving areas of significant unmet medical need.' Douglas Williams, PhD, Immunex Executive Vice President and Chief Technology Officer, said 'This new collaboration with CAT underscores our commitment to rapidly develop antibody based therapeutics to our validated proprietary targets. This agreement allows us to work with the skilled scientists and systems at CAT and to accelerate the development timelines on two important drug targets.' In November 2000, Immunex and CAT announced that Immunex received a licence from CAT to utilise its antibody library for reagent generation and target validation. Under that agreement, Immunex will also receive up to eight exclusive product options derived from its in house use of the CAT library and CAT would potentially receive clinical milestones and royalty payments on sales. -ENDS- Notes to Editors: Cambridge Antibody Technology (CAT) CAT is a UK biotechnology company using its proprietary technologies in human monoclonal antibodies for drug discovery and drug development. Based in Melbourn, 10 miles south of Cambridge, England, CAT currently employs around 220 people. CAT is listed on the London Stock Exchange, having raised £41m in its IPO in March 1997. A secondary offering in March 2000 raised £93m. CAT has a world-leading platform technology for rapidly isolating fully human monoclonal antibodies using phage display systems. CAT has an extensive phage antibody library, currently incorporating around 100 billion distinct antibodies. This library forms the basis for the company's strategy to develop a portfolio of clinical development programmes and for discovering new drug leads using functional genomics. Four human therapeutic antibodies developed by CAT are at various stages of clinical trials. CAT has a number of licence and collaborative agreements in place with pharmaceutical and biotechnology companies including: Eli Lilly, Pfizer, BASF Pharma (Abbott), Genentech, ICOS, Genetics Institute, Wyeth-Ayerst, Human Genome Sciences, AstraZeneca, Pharmacia, Oxford GlycoSciences, Genzyme, Zyomyx and Elan. Immunex Corporation Immunex Corporation is a leading biopharmaceutical company dedicated to improving lives through immune system science innovations. This press release contains statements about Cambridge Antibody Technology Group plc (CAT) that are forward looking statements. All statements other than statements of historical facts included in this press release may be forward looking statements. These forward looking statements are based on numerous assumptions regarding CAT's present and future business strategies and the environment in which CAT will operate in the future. Certain factors that could cause CAT's actual results, performance or achievements to differ materially from those in the forward looking statements include: market conditions, CAT's ability to enter into and maintain collaborative arrangements, success of product candidates in clinical trials, regulatory developments and competition.
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