Holding(s) in Company

Cambridge Antibody Tech Group PLC
12 April 2005

                                  SCHEDULE 10

                   NOTIFICATION OF MAJOR INTERESTS IN SHARES


1)   Name of company

Cambridge Antibody Technology Group plc


2)   Name of shareholder having a major interest

The Wellcome Trust


3)   Please state whether notification indicates that it is in respect of
     holding of the shareholder named in 2 above or in respect of a
     non-beneficial interest or in the case of an individual holder if it is a
     holding of that person's spouse or children under the age of 18

As in 2 above


4)   Name of the registered holder(s) and, if more than one holder, the
     number of shares held by each of them

State Street Nominees Limited Account JD12          23,252 Ordinary Shares
State Street Nominees Limited Account JD71          1,628,826 Ordinary Shares


5)   Number of shares/amount of stock acquired

Not Stated


6)   Percentage of issued class

N/A


7)   Number of shares/amount of stock disposed

Not Stated


8)   Percentage of issued class

N/A


9)   Class of security

Ordinary 10 pence shares


10)  Date of transaction

Not Stated


11)  Date company informed

12 April 2005


12)  Total holding following this notification

1,652,078


13)  Total percentage holding of issued class following this notification

3.20%


14)  Any additional information

None


15)  Name of contact and telephone number for queries

Justin Hoskins 01223 898589


16)  Name and signature of authorised company official responsible for
     making this notification

Justin Hoskins, Company Secretary


Date of notification: 12 April 2005





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