Holding(s) in Company

Cambridge Antibody Tech Group PLC
20 January 2005

                                  SCHEDULE 10

                   NOTIFICATION OF MAJOR INTERESTS IN SHARES


1)   Name of company

Cambridge Antibody Technology Group plc

2)   Name of shareholder having a major interest

Wellington Management Company, LLP

3)   Please state whether notification indicates that it is in respect of
     holding of the shareholder named in 2 above or in respect of a
     non-beneficial interest or in the case of an individual holder if it is a
     holding of that person's spouse or children under the age of 18

Non-beneficial

4)   Name of the registered holder(s) and, if more than one holder, the
     number of shares held by each of them

Investment Advisor - names of separate accounts not disclosed.  The shares are
registered in the name of the Accounts or the Accounts' custodians or nominees
according to their respective holdings.

5)   Number of shares/amount of stock acquired

Not disclosed

6)   Percentage of issued class

Not disclosed

7)   Number of shares/amount of stock disposed

Not disclosed

8)   Percentage of issued class

N/A

9)   Class of security

Ordinary 10 pence shares

10)  Date of transaction

Not disclosed

11)  Date company informed

19 January 2005

12)  Total holding following this notification

3,965,400 Ordinary 10 pence shares

13)  Total percentage holding of issued class following this notification

7.70%

14)  Any additional information

The Accounts do not act as a group nor do they act in concert with respect to
the interests in shares.

15)  Name of contact and telephone number for queries

Justin Hoskins 01223 898589

16)  Name and signature of authorised company official responsible for
     making this notification

Diane Mellett, Company Secretary



Date of notification: 20 January 2005








                                  SCHEDULE 10

                   NOTIFICATION OF MAJOR INTERESTS IN SHARES


1)   Name of company

Cambridge Antibody Technology Group plc

2)   Name of shareholder having a major interest

Legal & General Group plc

3)   Please state whether notification indicates that it is in respect of
     holding of the shareholder named in 2 above or in respect of a
     non-beneficial interest or in the case of an individual holder if it is a
     holding of that person's spouse or children under the age of 18

as in 2 above

4)   Name of the registered holder(s) and, if more than one holder, the
     number of shares held by each of them

Legal & General Group plc

5)   Number of shares/amount of stock acquired

Not disclosed

6)   Percentage of issued class

Not disclosed

7)   Number of shares/amount of stock disposed

Not disclosed

8)   Percentage of issued class

N/A

9)   Class of security

Ordinary 10 pence shares

10)  Date of transaction

Not disclosed

11)  Date company informed

20 January 2005

12)  Total holding following this notification

Not disclosed

13)  Total percentage holding of issued class following this notification

Not disclosed

14)  Any additional information

Legal & General Group plc and/or its subsidiaries no longer have a notifiable
interest in the shares of Cambridge Antibody Technology Group plc

15)  Name of contact and telephone number for queries

Justin Hoskins 01223 898589

16)  Name and signature of authorised company official responsible for
     making this notification

Diane Mellett, Company Secretary


Date of notification: 20 January 2005



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