Holding(s) in Company

Cambridge Antibody Tech Group PLC
24 May 2006


                   NOTIFICATION OF MAJOR INTERESTS IN SHARES



1. Name of company



CAMBRIDGE ANTIBODY TECHNOLOGY GROUP PLC



2. Name of shareholder having a major interest



BARCLAYS PLC



3. Please state whether notification indicates that it is in respect of holding
of the shareholder named in 2 above or in respect of a non-beneficial interest
or in the case of an individual holder if it is a holding of that person's
spouse or children under the age of 18



GERRARD LIMITED                                 NOT DISCLOSED

BARCLAYS LIFE ASSURANCE CO LIMITED              NOT DISCLOSED

BARCLAYS CAPITAL SECURITIES LIMITED             NOT DISCLOSED

BARCLAYS CAPITAL INC                            NOT DISCLOSED

BARCLAYS GLOBAL INVESTORS LIMITED               NOT DISCLOSED


4. Name of the registered holder(s) and, if more than one holder, the number of
shares held by each of them



GERRARD LIMITED                                       890

BARCLAYS LIFE ASSURANCE CO LIMITED                 63,867

BARCLAYS CAPITAL SECURITIES LIMITED               886,842

BARCLAYS CAPITAL INC                              170,000

BARCLAYS GLOBAL INVESTORS LIMITED                 618,986



5. Number of shares / amount of stock acquired



NOT DISCLOSED


6. Percentage of issued class



N/A



7. Number of shares / amount of stock disposed



NOT DISCLOSED



8. Percentage of issued class



N/A



9. Class of security



ORDINARY 10 PENCE SHARES



10. Date of transaction



17 MAY 2006

11. Date company informed



22 MAY 2006



12. Total holding following this notification



1,740,585



13. Total percentage holding of issued class following this notification



3.27%



14. Any additional information



NONE



15. Name of contact and telephone number for queries



JUSTIN HOSKINS 01223 898589



16. Name and signature of authorised company official responsible for making
this notification



JUSTIN HOSKINS, COMPANY SECRETARY



Date of notification



24 MAY 2006



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