Holding(s) in Company

Cambridge Antibody Tech Group PLC
23 September 2005

                   NOTIFICATION OF MAJOR INTERESTS IN SHARES



1. Name of company



Cambridge Antibody Technology Group plc



2. Name of shareholder having a major interest



Franklin Resources Inc.



3. Please state whether notification indicates that it is in respect of holding
of the shareholder named in 2 above or in respect of a non-beneficial interest
or in the case of an individual holder if it is a holding of that person's
spouse or children under the age of 18



Bank of New York                 non beneficial

JP Morgan Chase Bank             non beneficial

Citibank Nominees Limited        non beneficial

State Street Bank                non beneficial



4. Name of the registered holder(s) and, if more than one holder, the number of
shares held by each of them



Bank of New York                 22,229

JP Morgan Chase Bank             1,250,546

Citibank Nominees Limited        13,000

State Street Bank                283,314



5. Number of shares / amount of stock acquired



not disclosed



6. Percentage of issued class



not known



7. Number of shares / amount of stock disposed



None



8. Percentage of issued class



N/A



9. Class of security



Ordinary 10 pence shares



10. Date of transaction



Not disclosed



11. Date company informed



23 September 2005



12. Total holding following this notification



1,569,089



13. Total percentage holding of issued class following this notification



3.0385%



14. Any additional information



The disclosure has been made on behalf of Franklin Resources, Inc and its
affiliates which includes Franklin Mutual Advisers, LLC and Templeton Worldwide,
Inc. Franklin Resources, Inc and its affiliates perform investment management
advisory and related services for clients on a global basis.



15. Name of contact and telephone number for queries



Justin Hoskins 01223 898589



16. Name and signature of authorised company official responsible for making
this notification



Justin Hoskins, Company Secretary



Date of notification



23 September 2005



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