Holding in Company

Cambridge Antibody Tech Group PLC
16 March 2001


Schedule 10 - Notification of Major Interests in Shares

1   Name of company:
Cambridge Antibody Technology

2   Name of shareholder having a major interest:
FMR Corp, Fidelity International Limited, Edward C Johnson

3   Please state whether notification indicates that it is in respect of
holding of the shareholder named in 2 above or in respect of a non-beneficial
interest or in the case of an individual holder if it is a holding of that
person's spouse or children under the age of 18:
As in 2

4   Name of registered holder(s) and, if more than one holder, the number of
shares held by each of them:
Chase Nominees Limited (741,655) State Street Nominees Limited (268,500) HSBC
(1,249,906) Nortrust Nominees (370) State Street Nominees Limited (29,300)
Clydesdale Bank (Head Office) Nominees Limited (4,482) Chase Nominees Limited
(119,100) Bankers Trust (86,500) MSS Nominees Limited (12,200) Bank of New
York Europe (7,400) BT Globenet Nominees Limited (7,700) Nortrust Nominees
Limited (67,600) Chase Nominees Limited (80,000) RBS Trust Bank (81,000) HSBC
(17,900) Northern Trust (33,200) BT Globenet Nominees Limited (16,800) Morgan
Stanley (19,600) Bankers Trust (5,900) Bank of New York Europe (7,600)
Citibank (3,100)

5   Number of shares/amount of stock acquired:
384,230

6   Percentage of issued class:
1.09%

7   Number of shares/amount of stock disposed:
nil

8   Percentage of issued class:
nil

9   Class of security:
Ordinary 10p shares

10  Date of transaction:
Not disclosed

11  Date company informed:
16 March 2001

12  Total holding following this notification:
2,859,813

13  Total percentage holding of issued class following this notification:
8.08%

14  Contact name for queries:
Diane Mellett

15 Contact telephone number:
01763 263233

16  Name of company official responsible for making notification:
Company Secretary

17  Date of notification:
16 March 2001

Additional Information: