Holding in Company

Cambridge Antibody Tech Group PLC
15 September 2000

                  DEALINGS BY SUBSTANTIAL SHAREHOLDERS


1)   NAME OF COMPANY

CAMBRIDGE ANTIBODY TECHNOLOGY

2)   NAME OF SHAREHOLDER HAVING A MAJOR INTEREST

FMR CORP, FIDELITY INTERNATIONAL LIMITED, EDWARD C JOHNSON

3)   Please state whether notification indicates that it is in respect of 
     holding of the Shareholder named in 2 above or in respect of a 
     non-beneficial interest or in the case of an individual holder if it is a
     holding of that person's spouse or children under the age of 18

AS IN 2

4)   Name of the registered holder(s) and, if more than one holder, the 
     number of shares held by each of them.

CHASE NOMINEES LIMITED (684,055) STATE STREET NOMINEES LIMITED (227,800) LLOYDS
BANK NOMINEES LIMITED (827,196) NORTRUST NOMINEES (240) STATE STREET NOMINEES
LIMITED (19,100) CLYDESDALE BANK (HEAD OFFICE) NOMINEES LIMITED (4,482)

5)   Number of shares/amount of stock acquired.

310,240

6)   ( 0.9 %) of issued Class

7)   Number of shares/amount of stock disposed

NIL

8)   (NIL %) of issued Class

9)   Class of security

10p ORDINARY SHARES

10)  Date of transaction

NOT DISCLOSED

11)  Date company informed

14 SEPTEMBER 2000

12)  Total holding following this notification

1,762,873
               
              
13)  Total percentage holding of issued class following this notification

5.10%

14)  Any additional information



15)  Name of contact and telephone number for queries

DIANE MELLETT
01763 263232

16)  Name and signature of authorised company official responsible for 
     making this notification

     Date of Notification ....15 SEPTEMBER 2000.....