Holding in Company

Cambridge Antibody Tech Group PLC
3 November 2000



Schedule 10 - Notification of Major Interests in Shares

1   Name of company:
Cambridge Antibody Technology

2   Name of shareholder having a major interest:
FMR Corp, Fidelity International Limited, Edward C Johnson

3   Please state whether notification indicates that it is in respect of
holding of the shareholder named in 2 above or in respect of a non-beneficial
interest or in the case of an individual holder if it is a holding of that
person's spouse or children under the age of 18:
As in 2

4   Name of registered holder(s) and, if more than one holder, the number of
shares held by each of them:
Chase Nominees Limited (698,155) State Street Nominees Limited (283,100)
Lloyds Bank Nominees Limited (1,176,396) Nortrust Nominees (370) State Street
Nominees Limited (25,000) Clydesdale Bank (Head Office) Nominees Limited
(4,482)

5   Number of shares/amount of stock acquired:
424,630

6   Percentage of issued class:
1.21%

7   Number of shares/amount of stock disposed:
Nil

8   Percentage of issued class:
Nil

9   Class of security:
10p Ordinary Shares

10  Date of transaction:
Not disclosed

11  Date company informed:
3 November 2000

12  Total holding following this notification:
2,187,503

13  Total percentage holding of issued class following this notification:
6.23%

14  Contact name for queries:
Diane Mellett

15 Contact telephone number:
01763 263233

16  Name of company official responsible for making notification:
Company Secretary

17  Date of notification:
3 November 2000


Additional Information: