Holding in Company

Cambridge Antibody Tech Group PLC
1 August 2000


Schedule 10 - Notification of Major Interests in Shares

1   Name of company:
Cambridge Antibody Technology

2   Name of shareholder having a major interest:
Janus Capital Corporation

3   Please state whether notification indicates that it is in respect of
holding of the shareholder named in 2 above or in respect of a non-beneficial
interest or in the case of an individual holder if it is a holding of that
person's spouse or children under the age of 18:
Funds held on behalf of clients and funds managed

4   Name of registered holder(s) and, if more than one holder, the number of
shares held by each of them:
Not disclosed

5   Number of shares/amount of stock acquired:
248,388

6   Percentage of issued class:
0.72%

7   Number of shares/amount of stock disposed:


8   Percentage of issued class:


9   Class of security:
10p Ordinary shares

10  Date of transaction:
Not disclosed

11  Date company informed:
31 July 2000

12  Total holding following this notification:
3,170,379

13  Total percentage holding of issued class following this notification:
9.23%

14  Contact name for queries:
Diane Mellett

15 Contact telephone number:
01763 263233

16  Name of company official responsible for making notification:
Diane Mellett, Company Secretary

17  Date of notification:
1 Augist 2000

Additional Information: