Holding(s) in Company

Finsbury Life Sciences Inv Tst PLC
08 April 2005

SCHEDULE 10

NOTIFICATION OF MAJOR INTERESTS IN SHARES



1. Name of company


Finsbury Life Sciences Investment Trust PLC



2. Name of shareholder having a major interest


Prudential plc and subsidiaries



3. Please state whether notification indicates that it is in respect of holding
of the shareholder named in 2 above or in respect of a non-beneficial interest
or in the case of an individual holder if it is a holding of that person's
spouse or children under the age of 18


As in 2 above



4. Name of the registered holder(s) and, if more than one holder, the number of
shares held by each of them


PRUCLT HSBC GIS NOM(UK) PAC AC



5. Number of shares / amount of stock acquired


2,400,000



6. Percentage of issued class *


8.53%



7. Number of shares / amount of stock disposed


N/A



8. Percentage of issued class


-



9. Class of security


Ordinary shares of 25p each



10. Date of transaction


8 April 2005






11. Date company informed


 8 April 2005



12. Total holding following this notification


2,400,000



13. Total percentage holding of issued class following this notification*


8.53%



14. Any additional information


* Based on the issued share capital of 28,125,000 Ordinary shares, following a buy-back of shares for cancellation by
the Company of 1,975,000 on 7 April 2005.



15. Name of contact and telephone number for queries


Tracey Lago - 020 7426 6219



16. Name and signature of authorised company official responsible for making
this notification


Tracey Lago

For and on behalf of Close Finsbury Asset Management Limited



Date of notification


8 April 2005



The FSA does not give any express or implied warranty as to the accuracy of this
document or material and does not accept any liability for error or omission.
The FSA is not liable for any damages (including, without limitation, damages
for loss of business or loss of profits) arising in contract, tort or otherwise
from the use of or inability to use this document, or any material contained in
it, or from any action or decision taken as a result of using this document or
any such material.


                      This information is provided by RNS
            The company news service from the London Stock Exchange