Transaction in Own Shares

AstraZeneca PLC
03 October 2005


                     REPURCHASE OF SHARES IN ASTRAZENECA PLC

AstraZeneca PLC announced that on 30 September 2005, it purchased for
cancellation 500,000 ordinary shares of AstraZeneca PLC at a price of 2643 pence
per share. Upon the cancellation of these shares, the number of shares in issue
will be 1,597,276,472.

G H R Musker
Company Secretary
3 October 2005


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