Transaction in Own Shares

AstraZeneca PLC
22 September 2006



REPURCHASE OF SHARES IN ASTRAZENECA PLC


AstraZeneca PLC announced that on 21 September 2006, it purchased for
cancellation 350,000 ordinary shares of AstraZeneca PLC at a price of 3334 pence
per share. Upon the cancellation of these shares, the number of shares in issue
will be 1,552,843,271.



G H R Musker
Company Secretary
22 September 2006




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