Transaction in Own Shares

AstraZeneca PLC
21 September 2005


                    REPURCHASE OF SHARES IN ASTRAZENECA PLC


AstraZeneca PLC announced that on 20 September 2005, it purchased for
cancellation 1,000,000 ordinary shares of AstraZeneca PLC at a price of 2599
pence per share. Upon the cancellation of these shares, the number of shares in
issue will be 1,600,160,026.


G H R Musker
Company Secretary
21 September 2005


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