Transaction in Own Shares

AstraZeneca PLC
20 September 2005


                   REPURCHASE OF SHARES IN ASTRAZENECA PLC


AstraZeneca PLC announced that on 19 September 2005, it purchased for
cancellation 350,000 ordinary shares of AstraZeneca PLC at a price of 2637 pence
per share. Upon the cancellation of these shares, the number of shares in issue
will be 1,601,160,026.


G H R Musker
Company Secretary
20 September 2005




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