Transaction in Own Shares

AstraZeneca PLC
28 March 2007

                    REPURCHASE OF SHARES IN ASTRAZENECA PLC


AstraZeneca PLC announced that on 27 March 2007, it purchased for cancellation
1,306,258 ordinary shares of AstraZeneca PLC at a price of 2766 pence per share.

Some of these shares were purchased under the terms of the previously announced
irrevocable, non-discretionary share repurchase programme for the period 5
February 2007 to 30 April 2007.

Upon the cancellation of these shares, the number of shares in issue will be
1,512,647,594.


G H R Musker

Company Secretary

28 March 2007


                      This information is provided by RNS
            The company news service from the London Stock Exchange