Holding(s) in Company

AstraZeneca PLC 21 March 2007 TR-1: NOTIFICATION OF MAJOR INTERESTS IN SHARES 1. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attached: AstraZeneca PLC 2. Reason for the notification (place an X inside the appropriate bracket/s) An acquisition or disposal of voting rights: ( ) An acquisition or disposal of financial instruments which may result in the acquisition of shares already issued to which voting rights are attached: ( ) An event changing the breakdown of voting rights: ( ) Other (please specify) : ( X ) Compliance with the Transparency Directive 3. Full name of person(s) subject to the notification obligation: Capital Group International, Inc. 4. Full name of shareholder(s) (if different from 3.) : ................. 5. Date of the transaction (and date on which the threshold is crossed or reached if different): 15 March 2007 6. Date on which issuer notified: 16 March 2007 7. Threshold(s) that is/are crossed or reached: 5% 8. Notified details: ................. A: Voting rights attached to shares Class/type of shares if possible Situation previous to the Triggering transaction using the ISIN CODE Number of shares Number of voting Rights Ordinary Shares 58,717,220 58,717,220 American Depositary Receipt 23,499,200 23,499,200 Resulting situation after the triggering transaction Class/type of shares if Number of shares Number of voting rights % of voting rights possible using the ISIN CODE Direct Indirect Direct Indirect Direct Indirect Ordinary Shares 58,662,220 58,662,220 3.8617% American Depositary Receipt 23,208,206 23,208,206 1.5278% B: Financial Instruments Resulting situation after the triggering transaction Type of Expiration Date Exercise/Conversion Number of voting rights % of voting rights financial Period/ Date that may be acquired if the instrument instrument is exercised/ converted. N/A Total (A+B) Number of voting rights % of voting rights 81,870,426 5.378% 9. Chain of controlled undertakings through which the voting rights and/or the financial instruments are effectively held, if applicable: ................. Proxy Voting: 10. Name of the proxy holder: ................. 11. Number of voting rights proxy holder will cease to hold: ................. 12. Date on which proxy holder will cease to hold voting rights: ................. 13. Additional information: ................. 14. Contact name: Justin Hoskins - Assistant Secretary 15. Contact telephone number: 020 7304 5112 This information is provided by RNS The company news service from the London Stock Exchange

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AstraZeneca (AZN)
UK 100

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