Holding(s) in Company

AstraZeneca PLC
30 November 2005




Companies Act 1985 Section 198

Disclosure of Interest in Voting Shares in Public Companies



On 30 November 2005 we were informed by The Capital Group Companies, Inc., a
registered investment manager in the U.S., that on 28 November 2005 its interest
in the USD0.25 Ordinary Shares of AstraZeneca PLC had increased to 198,942,168
shares (12.54 per cent of the current issued ordinary capital) from the
previously notified level of 195,493,748 shares (12.30 per cent of the issued
ordinary capital at that time).  The reason for this announcement is that,
within the said holding of 12.54 per cent of the issued ordinary capital of
AstraZeneca PLC, Capital Guardian Trust Company, an affiliate of The Capital
Group Companies, Inc., has decreased its interest in these shares to 63,419,880
shares (3.99 per cent).



G H R Musker
Company Secretary
30 November 2005





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