Holding(s) in Company

AstraZeneca PLC
17 November 2005


Companies Act 1985 Section 198

Disclosure of Interest in Voting Shares in Public Companies

On 16 November 2005 we were informed by Wellington Management Company, LLP, a
registered investment advisor in the U.S., that on 16 November 2005 its interest
in the USD0.25 Ordinary Shares of AstraZeneca PLC had decreased to 79,405,884
shares (4.99 per cent of the current issued ordinary capital) from the
previously notified level of 81,304,301 shares (5.03  per cent of the issued
ordinary capital at that time).

G H R Musker
Company Secretary
17 November 2005


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