Holding(s) in Company

AstraZeneca PLC
05 July 2006



Companies Act 1985 Section 198

Disclosure of Interest in Voting Shares in Public Companies


On 4 July 2006 we were informed by Barclays PLC, that on 27 June 2006 its
interest in the USD0.25 Ordinary Shares of AstraZeneca PLC had increased to
62,731,921 shares (4.00 per cent of the current issued ordinary capital) from
the previously notified level of 50,634,731 shares (3.05 per cent of the issued
ordinary capital at that time).





G H R Musker

Company Secretary

5 July 2006



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