Holding(s) in Company

AstraZeneca PLC
28 October 2005



Companies Act 1985 Section 198
Disclosure of Interest in Voting Shares in Public Companies


On 28 October 2005, we were informed by The Capital Group Companies, Inc., a
registered investment manager in the US, that on 26 October 2005 its interest in
the USD0.25 Ordinary Shares of AstraZeneca PLC had decreased to 191,083,356
shares (11.96 per cent of the current issued ordinary capital) from the
previously notified level of 211,948,875 shares (12.94 per cent).


G H R Musker
Company Secretary
28 October 2005



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