Holding(s) in Company

AstraZeneca PLC
07 February 2007

Transparency Directive

Notification of Major Interests in Shares

On 6 February 2007 we were informed by Legal & General Investment Management
Limited that its interest in the USD0.25 Ordinary Shares of AstraZeneca PLC as
at that date was 55,993,193 shares (3.65 per cent of the current issued ordinary
capital).  Each ordinary share carries the right to one vote in relation to all
circumstances at general meetings of AstraZeneca PLC.

This notification is being made in accordance with the FSA's Disclosure and
Transparency Rules.

G H R Musker

Company Secretary

7 February 2007



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