Holding(s) in Company

AstraZeneca PLC
20 December 2005


Companies Act 1985 Section 198

Disclosure of Interest in Voting Shares in Public Companies


On 19 December 2005 we were informed by Wellington Management Company, LLP, a
registered investment advisor in the U.S., that on 19 December 2005 its interest
in the USD0.25 Ordinary Shares of AstraZeneca PLC had decreased to 78,671,049
shares (4.98 per cent of the current issued ordinary capital) from the
previously notified level of 79,723,952 shares (5.02  per cent of the issued
ordinary capital at that time).


G H R Musker

Company Secretary

20 December 2005


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