Holding(s) in Company

AstraZeneca PLC
22 August 2006



Companies Act 1985 Section 198

Disclosure of Interest in Voting Shares in Public Companies



On 22 August 2006 we were informed by Barclays PLC, that on 16 August 2006 its
interest in the USD0.25 Ordinary Shares of AstraZeneca PLC had decreased to
60,890,928 shares (3.90 per cent of the current issued ordinary capital) from
the previously notified level of 71,754,726 shares (4.60 per cent of the issued
ordinary capital at that time).


G H R Musker
Company Secretary
22 August 2006



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