Holding(s) in Company

AstraZeneca PLC
18 August 2006


Companies Act 1985 Section 198
Disclosure of Interest in Voting Shares in Public Companies

On 18 August 2006 we were informed by Barclays PLC, that on 11 August 2006 its
interest in the USD0.25 Ordinary Shares of AstraZeneca PLC had increased to
80,177,587 shares (5.14 per cent of the current issued ordinary capital) from
the previously notified level of 73,107,396 shares (4.68 per cent of the issued
ordinary capital at that time).

G H R Musker
Company Secretary
18 August 2006



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