Director/PDMR Shareholding

AstraZeneca PLC
28 March 2006

Transaction by Persons Discharging Managerial Responsibilities
Disclosure Rules DR 3.1.2R

We hereby inform you that on 27 March 2006, Anthony Zook, Executive
Vice-President, North America, a person discharging managerial responsibilities,
exercised an option over 30,990 AstraZeneca PLC American Depositary Shares
(ADSs) at an option price of $35.16 per ADS.  One ADS equals one Ordinary Share.

We also inform you that on 27 March 2006, Mr Zook sold 24,790 of the ADSs
acquired from the exercise at an average price of $50.39 per ADS.  The sale was
effected to cover the cost of exercising the option and to meet certain
immediate tax liabilities.  Mr Zook has retained the remaining 6,200 ADSs.

G H R Musker
Company Secretary
28 March 2006


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