Director/PDMR Shareholding

AstraZeneca PLC
02 December 2005

Transaction by Persons Discharging Managerial Responsibilities

Disclosure Rules DR 3.1.2R





We hereby inform you that on 1 December 2005, Dr Barrie Thorpe, Executive
Vice-President, Operations, a person discharging managerial responsibilities,
acquired an interest in 226 AstraZeneca PLC USD0.25 Ordinary Shares at a price
of 1756 pence per share following the exercise of an option under the
AstraZeneca Savings Related Share Option Scheme.





G H R Musker

Company Secretary

2 December 2005


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