Director/PDMR Shareholding

AstraZeneca PLC
27 February 2007

Transaction by Persons Discharging Managerial Responsibilities
Disclosure Rules DR 3.1.2R


We hereby inform you that on 23 February 2007, the following individuals, who
are all persons discharging managerial responsibilities, acquired an interest in
the USD0.25 Ordinary Shares of AstraZeneca PLC or, in the case of A Zook, over
the Company's American Depositary Shares (ADSs).  One ADS equals one Ordinary
Share.  The interest arises as a result of the previously disclosed arrangements
relating to the payment of annual bonuses for 2006 whereby each individual is
required to defer a portion of the bonus earned into shares for a period of
three years.  The shares are awarded under the terms of the AstraZeneca Deferred
Bonus Plan.  The individuals will become beneficially entitled to these shares
on 23 February 2010.


                                Number of shares    Award price per
Name                            allocated           share

B Angelici                      1,984               2911p

A Bloxham                       1,366               2911p

J Lundberg                      1,762               2911p

M Nicklasson                    1,803               2911p

D Smith                         982                 2911p

A Zook                          1,755               US$57.19



G H R Musker
Company Secretary
27 February 2007


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