Director/PDMR Shareholding

AstraZeneca PLC
27 February 2007

Dealing by Directors
Companies Act 1985 Sections 324/329



Transaction by Persons Discharging Managerial Responsibilities
Disclosure Rules DR 3.1.2R



We hereby inform you that on 23 February 2007, the following Directors acquired
an interest in the USD0.25 Ordinary Shares of AstraZeneca PLC.  The interest
arises as a result of the previously disclosed arrangements relating to the
payment of annual bonuses for 2006 whereby each individual is required to defer
a portion of the bonus earned into shares for a period of three years.  The
shares were allocated at a price of 2911 pence per share.  The individuals will
become beneficially entitled to these shares on 24 February 2010.


                       Number of shares         Total interest in shares     Percentage of shares in
                       allocated                after this allocation        issue
Name


J R Symonds            6,491                    114,921                      0.008%


J S Patterson          5,600                    94,502                       0.006%









G H R Musker
Company Secretary
27 February 2007


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