Director/PDMR Shareholding

AstraZeneca PLC
05 December 2007

Transaction by Persons Discharging Managerial Responsibilities

Disclosure Rules DR 3.1.4R





We hereby inform you that AstraZeneca PLC has received notice under DTR 3.1.2R
that, on 30 November 2007, David Mott, President and Chief Executive Officer of
MedImmune Inc., a person discharging managerial responsibilities, was awarded
59,435 AstraZeneca American Depositary Shares (ADSs) under the terms of the
AstraZeneca Pharmaceuticals LP Restricted Stock Unit Award Plan at an award
price of USD47.11 per ADS.  One ADS equals one Ordinary Share.  The award is
expected to vest on 18 June 2009 subject to the rules of the Plan at which time
Mr Mott will become beneficially entitled to the 59,435 ADSs providing that he
remains in employment until that time.





G H R Musker

Company Secretary

5 December 2007


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