Director/PDMR Shareholding

AstraZeneca PLC
28 March 2007


Dealing by Directors

Companies Act 1985 Sections 324/329


Transaction by Persons Discharging Managerial Responsibilities

Disclosure Rules DR 3.1.2R


We hereby inform you that the interest of David R. Brennan, a Director of the
Company, in the shares of AstraZeneca PLC has changed as detailed below.  Mr
Brennan has interests in both the Ordinary Shares and the American Depositary
Shares (ADSs) of AstraZeneca PLC.  One ADS equals one Ordinary Share.


On 26 March 2007, Mr Brennan became unconditionally entitled to a final award of
15,566 ADSs on the partial vesting of an original target award of 28,826 ADSs,
which were awarded to him in March 2004 under the terms of the AstraZeneca US
Executive Performance Share Plan.  Mr Brennan has ceased to have an interest in
the 13,260 ADSs of the original target award that did not vest.  After certain
mandatory tax deductions, Mr Brennan has received 9,332 ADSs into a personal
brokerage account.


The closing price of AstraZeneca ADSs on 26 March 2007 was US$54.73.


Immediately prior to the above transactions, Mr Brennan had an interest in
110,567 Ordinary Shares and 160,297 AstraZeneca ADSs.  As a result of these
transactions, Mr Brennan now has an interest in 110,567 Ordinary Shares and
140,803 AstraZeneca ADSs.  This interest represents approximately 0.017% of the
Company's issued ordinary capital.


G H R Musker

Company Secretary

28 March 2007


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