Director/PDMR Shareholding

AstraZeneca PLC
15 December 2005


Dealing by Directors

Companies Act 1985 Sections 324/329


Transaction by Persons Discharging Managerial Responsibilities

Disclosure Rules DR 3.1.2R


We hereby inform you that on 14 December 2005 Sir Tom McKillop, a Director of
the Company, sold 77,774 AstraZeneca PLC USD0.25 Ordinary Shares at a price of
2749 pence per share.


The sale of these shares at this time by Sir Tom is based on independent,
personal financial advice received by him in the context of tax planning for his
retirement from the Board of AstraZeneca PLC at the end of 2005.  In order to
take full advantage of the taper relief on the capital gain incurred on the sale
of these shares, it was necessary for the sale to occur while Sir Tom is still
employed by the Company.


Following this sale, Sir Tom McKillop's total holding in the Company is 119,258
shares, which represents approximately 0.008% of the issued ordinary capital of
the Company.  This total includes a conditional entitlement to a target award of
104,417 shares granted under the AstraZeneca Performance Share Plan in June
2005.  Sir Tom also holds options over 678,481 Ordinary Shares in the Company
granted under two executive share option schemes.


G H R Musker

Company Secretary

15 December 2005


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