Holding in Company

Microgen PLC
12 December 2001



                  DEALINGS BY SUBSTANTIAL SHAREHOLDERS


1)   NAME OF COMPANY

     MICROGEN PLC

2)   NAME OF SHAREHOLDER HAVING A MAJOR INTEREST

     SCHRODER INVESTMENT MANAGEMENT LIMITED

3)   Please state whether notification indicates that it is in respect of 
     holding of the Shareholder named in 2 above or in respect of a 
     non-beneficial interest or in the case of an individual holder if it is a
     holding of that person's spouse or children under the age of 18

     SHAREHOLDER

4)   Name of the registered holder(s) and, if more than one holder, the 
     number of shares held by each of them.

     SCHRODER UNIT TRUSTS LTD                          - 6,032,458
     NORTRUST NOMINEES LTD                             -   500,000
     NUTRACO NOMINEES LTD                              -   162,300
     IMPERIAL PENSIONS NOMINEES LTD                    -   475,000
     SCHRODER INVESTMENT MANAGEMENT NORTH AMERICA INC. -   960,000

5)   Number of shares/amount of stock acquired.

     -

6)   ( - %) of issued Class

7)   Number of shares/amount of stock disposed

     910,242

8)   ( 1.78%) of issued Class

9)   Class of security

     5p ORDINARY SHARES

10)  Date of transaction

     NOT KNOWN

11)  Date company informed

     11 DECEMBER 2001

12)  Total holding following this notification

     8,129,758
               
13)  Total percentage holding of issued class following this notification

     15.87%

14)  Any additional information



15)  Name of contact and telephone number for queries

     G E LIDDLE [phone]

16)  Name and signature of authorised company official responsible for 
     making this notification

     Date of Notification 12 DECEMBER 2001