Holding in Company

Microgen PLC
2 January 2002



                  DEALINGS BY SUBSTANTIAL SHAREHOLDERS


1)   NAME OF COMPANY

     MICROGEN PLC

2)   NAME OF SHAREHOLDER HAVING A MAJOR INTEREST

     SCHRODER INVESTMENT MANAGEMENT LIMITED

3)   Please state whether notification indicates that it is in respect of 
     holding of the Shareholder named in 2 above or in respect of a 
     non-beneficial interest or in the case of an individual holder if it is a
     holding of that person's spouse or children under the age of 18

     SHAREHOLDER

4)   Name of the registered holder(s) and, if more than one holder, the 
     number of shares held by each of them.

     SCHRODER UNIT TRUSTS LTD - 6,032,458
     NORTRUST NOMINEES LTD - 500,000
     NUTRACO NOMINEES LTD - 162,300
     IMPERIAL PENSIONS NOMINEES LTD - 475,000
     SCHRODER INVESTMENT MANAGEMENT NORTH AMERICA INC - 960,000
     HSBC GLOBAL CUSTODY NOMINEE (UK) LTD - 310,800

5)   Number of shares/amount of stock acquired.

     310,800

6)   ( 0.61 %) of issued Class

7)   Number of shares/amount of stock disposed



8)   ( N/A %) of issued Class

9)   Class of security

     5P ORDINARY SHARES

10)  Date of transaction

     NOT KNOWN 

11)  Date company informed

     2 JANUARY 2002

12)  Total holding following this notification

     8,440,558
               
13)  Total percentage holding of issued class following this notification

     16.48%

14)  Any additional information



15)  Name of contact and telephone number for queries

     G.E. LIDDLE
     [phone]

16)  Name and signature of authorised company official responsible for 
     making this notification     G.E. LIDDLE
                                  COMPANY SECRETARY

     Date of Notification ....2 JANUARY 2002....................