Holding in Company

Microgen PLC
13 August 2001


                  DEALINGS BY SUBSTANTIAL SHAREHOLDERS


1)   NAME OF COMPANY

     MICROGEN PLC

2)   NAME OF SHAREHOLDER HAVING A MAJOR INTEREST

     LEGAL AND GENERAL INVESTMENT MANAGEMENT

3)   Please state whether notification indicates that it is in respect of 
     holding of the Shareholder named in 2 above or in respect of a 
     non-beneficial interest or in the case of an individual holder if it is a
     holding of that person's spouse or children under the age of 18

     SHAREHOLDER

4)   Name of the registered holder(s) and, if more than one holder, the 
     number of shares held by each of them.

     HSBC GLOBAL CUSTODY NOMINEE (UK) LTD A/C 887711    -      363,440
     HSBC GLOBAL CUSTODY NOMINEE (UK) LTD A/C 775245    -      462,618
     HSBC GLOBAL CUSTODY NOMINEE (UK) LTD A/C 360509    -       18,000
     HSBC GLOBAL CUSTODY NOMINEE (UK) LTD A/C 357206    -    1,104,335
     HSBC GLOBAL CUSTODY NOMINEE (UK) LTD A/C 747381    -       49,000
     HSBC GLOBAL CUSTODY NOMINEE (UK) LTD A/C 866203    -       40,000


5)   Number of shares/amount of stock acquired.

     5,000

6)   (0.01%) of issued Class

7)   Number of shares/amount of stock disposed

     -

8)   ( - %) of issued Class

9)   Class of security

     5P ORDINARY SHARES

10)  Date of transaction

     9 AUGUST 2001

11)  Date company informed

     13 AUGUST 2001

12)  Total holding following this notification

     2,037,393
               
13)  Total percentage holding of issued class following this notification

     3.98%

14)  Any additional information



15)  Name of contact and telephone number for queries

     G.E. LIDDLE      01753 847133

16)  Name and signature of authorised company official responsible for 
     making this notification

     Date of Notification .....13 AUGUST 2001...................