Holding in Company

Microgen PLC
13 March 2001


                  DEALINGS BY SUBSTANTIAL SHAREHOLDERS


1)   NAME OF COMPANY

     MICROGEN PLC

2)   NAME OF SHAREHOLDER HAVING A MAJOR INTEREST

     1. LEONARD GEORGE CRISP
     2. HILARY CRISP

3)   Please state whether notification indicates that it is in respect of 
     holding of the Shareholder named in 2 above or in respect of a 
     non-beneficial interest or in the case of an individual holder if it is a
     holding of that person's spouse or children under the age of 18

     SHAREHOLDERS

4)   Name of the registered holder(s) and, if more than one holder, the 
     number of shares held by each of them.

     LEONARD GEORGE CRISP    1,807,252
     HILARY CRISP (SPOUSE)     980,888
                             ---------
                             2,788,140

5)   Number of shares/amount of stock acquired.

     922,962

6)   (1.8%) of issued Class

7)   Number of shares/amount of stock disposed



8)   ( N/A %) of issued Class

9)   Class of security

     5p ORDINARY SHARES

10)  Date of transaction

     NOT KNOWN

11)  Date company informed

     9 MARCH 2001

12)  Total holding following this notification

     LEONARD GEORGE CRISP  1,562,771
     HILARY CRISP          2,148,331
               
13)  Total percentage holding of issued class following this notification

     LEONARD GEORGE CRISP    3.05%
     HILARY CRISP            4.20%

14)  Any additional information

     940,462 TRANSFERRED FROM NON-BENEFICIAL TO BENEFICIAL

       2,500 PURCHASED BY L G CRISP 12 FEBRUARY 2001

15)  Name of contact and telephone number for queries

     K E TAPPING (01753 847155)

16)  Name and signature of authorised company official responsible for 
     making this notification

     Date of Notification ..13 MARCH 2001