Holding in Company

Microgen PLC
21 November 2000


                  DEALINGS BY SUBSTANTIAL SHAREHOLDERS


1)   NAME OF COMPANY

MICROGEN PLC


2)   NAME OF SHAREHOLDER HAVING A MAJOR INTEREST

EDINBURGH FUND MANAGERS GROUP PLC


3)   Please state whether notification indicates that it is in respect of 
     holding of the Shareholder named in 2 above or in respect of a 
     non-beneficial interest or in the case of an individual holder if it is a
     holding of that person's spouse or children under the age of 18

SHAREHOLDER 


4)   Name of the registered holder(s) and, if more than one holder, the 
     number of shares held by each of them.

MINEWORKERS PENSION SCHEME (CHASE GIS) NOMINEES LTD           815,300
BRITISH COAL STAFF SUPERANNUATION SCHEME (CHASE GIS)
 NOMINEES LTD                                                 815,300
RBSTB NOMINEES LTD                                          3,573,730
VIDACOS NOMINEES LTD                                          251,800
CITY OF EDINBURGH COUNCIL                                     227,914


5)   Number of shares/amount of stock acquired.

 540,000

6)   (1.05%) of issued Class

7)   Number of shares/amount of stock disposed



8)   ( N/A %) of issued Class

9)   Class of security

5P ORDINARY SHARES

10)  Date of transaction

21 NOVEMBER 2000

11)  Date company informed

21 NOVEMBER 2000

12)  Total holding following this notification

5,684,044
               
              
13)  Total percentage holding of issued class following this notification

11.1%

14)  Any additional information



15)  Name of contact and telephone number for queries

G E LIDDLE   01753 847133

16)  Name and signature of authorised company official responsible for 
     making this notification

     Date of Notification ..21 NOVEMBER 2000