Joint Venture

Angle PLC 22 September 2004 For Immediate Release 22 September 2004 ANGLE plc DEVELOPMENT OF HEART HEALTHY DRINK PROVEXIS ANNOUNCES JOINT VENTURE WITH NUTRINNOVATOR ANGLE plc, ('ANGLE'), is pleased to announce that venture Company, Provexis Limited has agreed a joint venture with Nutrinnovator Holdings plc to develop a new heart-healthy drink. The drink will be the first of its kind; a juice drink containing a patented natural fruit extract which has been proven in human trials to 'thin' the blood and benefit the circulation. Provexis collaborated with the Rowett Institute (a leading human nutrition research centre) over a four year period to develop and clinically test a patented ingredient called CardioFlow(R). CardioFlow(R) works by reducing the 'stickiness' of blood platelets which prevents them from self-aggregating and potentially initiating a fatal internal blood clot called a thrombus. The natural fruit-derived extract is proven to provide real health benefits without affecting the taste, and without the side-effects typically associated with aspirin. The joint venture partners believe that the product will exploit an untapped market opportunity. It is expected that development of a commercial product will be ready for UK launch in May 2005, and the joint venture plans to expand distribution into the USA and Japan thereafter. In Europe, approximately 40% of all deaths can be attributed to circulatory diseases, the driving force behind the $4bn global market for products that have proven heart health benefits. Provexis Limited was founded by ANGLE in 2000 using its established Progeny(R) process as a joint venture with the Rowett Institute. ANGLE retains a 32% holding in Provexis. The venture will be 55% owned by Provexis and product development will be funded from Nutrinnovator's existing cash resources. Commenting on the joint venture, Dr Stephen Franklin, CEO of Provexis said: 'We are delighted to announce the development of our Cardioflow product. 'Findings show that regular consumption of CardioFlow(R) make a significant contribution to maintaining cardiovascular health, thereby reducing the risk of a heart attack, stroke or Deep Vein Thrombosis (DVT).' 'The integration of CardioFlow(R) into a new branded beverage comes even earlier than we had anticipated. The juice drink is just one example of the potential opportunities open to Provexis, for the addition of CardioFlow through the consumer food and drink market.' Commenting on the joint venture, Andrew Newland, Chief Executive of ANGLE plc said: 'The potential for ANGLE's venture company Provexis in the world cardiovascular health market is significant and follows four years of hard work and investment. 'The development of this heart-healthy drink through the joint venture with Nutrinnovator further demonstrates the value generation capability of ANGLE's Progeny(R) process for commercialising intellectual property.' For further information ANGLE plc 01483 295830 Andrew Newland, Chief Executive Dawson Buck, Deputy Chief Executive Buchanan Communications 020 7466 5000 Richard Darby, Suzanne Brocks Notes to Editors Founded in 1994, ANGLE is an international venture management and consulting company focusing on the commercialisation of technology and the development of technology-based industry. ANGLE creates, develops and advises technology businesses on its own behalf and for its clients. ANGLE plc floated on the Alternative Investment Market of the London Stock Exchange on 17 March 2004. Nuttrinovator Holdings plc Nutrinnovator develops and markets food and drink products of superior nutritional quality, whilst retaining high quality taste, palatability and consumer appeal. This information is provided by RNS The company news service from the London Stock Exchange KDKBFBKDQCB

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