Holding(s) in Company

Alliance Pharma PLC
11 November 2004

Amendment #1

NOTIFICATIONS UNDER SECTIONS 198 TO 202 -- UK COMPANIES ACT

1. Company in which shares are held:    Alliance Pharma Plc

2. Notifiable Interest:     Ordinary Shares

     A     FMR Corp
           82 Devonshire Street
           Boston, MA 02109

           Parent holding company of Fidelity Management & Research Company 
           (FMRCO), investment manager for US mutual funds (See Schedule A for 
           listing of Registered Shareholders and their holdings.)

     B     Fidelity International Limited (FIL)
           P.O. BOX HM 670
           Hamilton HMCX, Bermuda

           Parent holding company for various direct and indirect subsidiaries,
           (See Schedule A for listing of Registered Shareholders and 
           their holdings).

3.     The notifiable interests also comprise the notifiable interest of

           Mr Edward C Johnson 3d
           82 Devonshire Street
           Boston, MA 02109

           A principal shareholder of FMR Corp. and Fidelity 
           International Limited.

4.     The notifiable interests include interest held on behalf of authorized
       unit trust schemes in the U.K. notwithstanding the exemption from 
       reporting pursuant to Section 209 (1)(h)of the Companies Act 1985.

5.     These notifications of disclosable interests constitute separate
       notifications of interest in the shares and are combined solely for 
       the purposes of clarity and efficiency.  Nothing herein should be taken 
       to indicate that FMR Corp. and its direct and indirect subsidiaries, 
       Fidelity International Limited and its direct and indirect subsidiaries
       or Mr Edward C Johnson 3d act as a group or in concert in respect of 
       the disclosed interests, or that they are required to submit these 
       notifications on a joint basis.

6.     The disclosable interests arise under section 208(4) (b) of the Act,
       namely where a person, not being the registered holder, is entitled
       to exercise a right conferred by the holding of the shares or to 
       control the exercise of such rights, or under section 203 of the Act
       respectively.

SCHEDULE A

SECURITY: Alliance Pharma Plc                                  Amendment # 1


                      SHARES HELD   MANAGEMENT   NOMINEE/REGISTERED
                                     COMPANY     NAME

                         240,500       FIL       Brown Brothers Harriman Ltd.
                                                 LUX Total
                       6,259,500     FMRCO       Mellon Bank Total
                       6,500,000                 Grand Total Ordinary Shares

                     
CURRENT OWNERSHIP PERCENTAGE:  4.41%

SHARES IN ISSUE:         147,355,890

CHANGE IN HOLDINGS IS WHOLLY DUE TO THE INCREASE IN THE SHARE CAPITAL FIGURE
 






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