Blocklisting Interim Review

Shires Smaller Companies PLC
22 December 2005


                                   SCHEDULE 5

                        BLOCKLISTING SIX MONTHLY RETURN


1. Name of company SHIRES SMALLER COMPANIES PLC


2. Name of scheme BLOCK LISTING


3. Period of return: From 22 APRIL 2005 to 21 OCTOBER 2005


4. Number and class of shares(s)
(amount of stock/debt security)
not issued under scheme 826,773


5. Number of shares issued/allotted
under scheme during period NIL


6. Balance under scheme not yet issued/allotted
at end of period 826,773


7. Number and class of share(s)
(amount of stock/debt securities)
originally listed and the date of admission 900,000

Please confirm total number of shares in issue at the end of the period
in order for us to update our records 22,109,765

Contact for queries: Address:

Name: GRAEME MCDONALD SUTHERLAND HOUSE, 149 ST VINCENT STREET, GLASGOW

Telephone: [phone]






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