Contract Win

Embargoed Release: 07:00hrs Wednesday 19 January 2005

                                  SOPHEON PLC                                  

                                  (`Sopheon')                                  

 Atrium Medical Center Selects Sopheon's Accolade Solution to Manage Clinical  
                        Trials and Innovation Projects                         

    Software Will Support Compliance with New European-Union Clinical Trial    
   Regulations and Help Ensure Projects Are Executed Efficiently and On Time   

Sopheon, the international provider of solutions that improve the return from
innovation and product development, announces that Atrium Medical Center, one
of the largest general hospitals in the Netherlands, is deploying Sopheon's
Accolade solution to support implementation of a structured process for
comprehensive management of clinical trials. Use of the software is expected to
help Atrium enhance management of trials activity and ensure compliance with
the latest European Union (EU) clinical research regulations. Accolade will
also be used by the hospital to manage innovation projects, including major
capital investment initiatives.

'Pharmaceutical companies judge our clinical-trial work by the quality of the
results and the speed and cost-effectiveness with which those results are
delivered,' said Dr. Graham Ramsay of Atrium's board. 'Patients depend upon our
ability to effect the right kinds of innovation and make the right capital
investments to ensure that they receive the best available care. Sopheon's
software will integrate our processes for managing clinical trials and
innovation projects, making those processes more stable, predictable and
efficient.'

The hospital is deploying Accolade at its facilities in Heerlen, Kerkrade and
Brunssum. Atrium conducts approximately 70 clinical trials per year for leading
pharmaceutical companies. It is anticipated that use of the software system,
which will eventually handle as many as 240 trials at one time, will increase
clinical-trials revenue by enabling faster trial preparation and execution,
higher quality results and improved service to clients. Sopheon also worked
closely with Atrium to configure Accolade to fit a new, jointly-developed
process incorporating elements of the Six Sigma manufacturing methodology that
will be applied to management of innovation initiatives.

Accolade will replace the manual, paper-based process structure that Atrium
previously used to manage clinical trials with a reliable, easy-to-use
Web-based framework for everything from tracking schedules and budgets to
assessing and allocating resources, conducting financial analyses and examining
trial results. The system provides hospital executives, managers, clinical
trial coordinators, doctors and researchers with the information support
required for tactical, day-to-day management activity as well as for strategic,
longer-term business decision-making. Atrium plans to extend access to the
system to pharmaceutical clients interested in checking on the status of trial
projects involving their products.

Sopheon's CEO Andy Michuda said:

'Clinical trial management is a critical step in the cycle that moves
pharmaceutical products from conception and development to safe adoption in the
marketplace. It's estimated that, in the United States alone, approximately
80,000 clinical trials are being conducted at any one time. The scale of
opportunity associated with effecting improvements in this area is great.
Accolade's capacity to reduce the expense and inefficiency of the clinical
trial process has led to its adoption by some of the leading clinical hospitals
in the world. Atrium is one such leader, and a prime example of how forward
thinking healthcare providers are harnessing technology to benefit stakeholders
throughout the value chain.'

For further information contact:

Barry Mence, Chairman  Sopheon plc                  Tel : + 44 (0) 1483 685   
                                                    735                       
Arif Karimjee, CFO                                                            
                                                                              
Adam Reynolds          Hansard Communications       Tel : + 44 (0) 207 245    
                                                    1100                      
Andrew Tan                                                                    
                                                    + 44 (0) 7957 203 685     
                                                                              
Barbara Jansen         Citigate First Financial     Tel : + 31 (0) 205 754 010

About Atrium Medical Center

With 3600 employees and 1230 beds, Atrium Medical Center (Atrium) is one of the
largest employers in the south of the Netherlands. In 2004 Atrium celebrated
its 100-year anniversary. It has a national reputation for hospital innovation,
and has recently participated in experimental studies on reducing patient
wait-lists, increasing care-delivery production, implementing new budgetary
systems and improving patient safety. In 2003, supported by a €187 million
budget, Atrium registered 28,000 clinical admissions, 24,000 day admissions and
432,000 patient visits to its policlinics. Atrium's focus on patients,
professionalism, and continuity and effectiveness of treatment ensures that the
quality of care it provides remains on the highest levels.

About Sopheon

Sopheon (LSE: SPE) is an international provider of software and services. The
Sopheon Accolade product development system automates gate- or phase-based
product development processes and provides strategic decision support that
allows companies to improve innovation, cut product development spending waste
and shorten time-to-market. Sopheon's Monitor software operates as a 'reading
robot' that automatically reviews, filters, analyzes and pushes relevant
content to healthcare and engineering professionals to enable effective
compliance with protocols, standards and regulations. Sopheon is listed on the
AIM Market of the London Stock Exchange and on the Euronext in the Netherlands.
For more information, please visit www.sopheon.com.