Statement re: Issuance of Patent

PROTEOME SCIENCES plc                             

                                 PRESS RELEASE                                 

                         Issuance of US Stroke Patent                          

11th December 2006. Proteome Sciences plc is pleased to announce the issuance
of US Patent Number 7,144,705 entitled "Diagnostic Assay for Stroke". The
claims of the patent relate to methods of diagnosing stroke by measuring the
levels of heart fatty acid binding protein (H-FABP), one of Proteome Sciences'
proprietary biomarkers discovered in the blood of stroke patients.

The presence of H-FABP in the blood of patients suffering from stroke was first
discovered in 1999 by scientists working at the University of Geneva in a
collaboration with Proteome Sciences. The two parties have worked extensively
since that time to validate its utility for diagnosing and monitoring the
progression of stroke. This has resulted in the discovery of further protein
biomarkers, all of which are subject to patent applications in the major patent
jurisdictions including the US, Europe and the Far East, from which
combinations of stroke markers will be used to make panels for the diagnosis
and prognosis of stroke in blood.

Proteome Sciences has previously announced four licensing agreements relating
to its portfolio of stroke biomarkers. Its licensees continue to undertake
their respective development programmes and the company looks forward to
further progress with both existing and future licensees in 2007.

Commenting on the issuance Christopher Pearce, Chief Executive of Proteome
Sciences said:

"The issuance of a US patent on one of our earliest biomarker candidates is a
significant milestone for the company. It validates the patentability of
proteomics biomarkers in the largest economic market and underpins the value
and importance of our extensive intellectual property portfolio in protein
biomarkers.

We anticipate the issuance of further patents relating to H-FABP in other
territories following on from the US allowance and that the patent applications
for the other stroke biomarkers will proceed to grant.

The issuance of the first US patent relating to our stroke biomarkers will
enhance the continuing licensing process and we expect that further of the
major global players in clinical diagnostics will now want to include and
develop our biomarkers as in vitro diagnostic tests."

                                     Ends                                      

Notes to editors:

Proteome Sciences plc

Proteome Sciences, a global leader in applied proteomics, uses high sensitivity
proprietary technologies to detect differentially expressed proteins in
diseases. The protein biomarkers discovered in body fluids or tissues are
validated, developed and commercialised as diagnostic, prognostic or
therapeutic products through strategic alliances and out-licensing.

Through its unique ProteoSHOP® toolbox, Proteome Sciences provides high
sensitivity/high throughput proteomics solutions, including traditional two
dimensional gel-based electrophoresis (2DE) and proprietary gel-free protein
sequence tag technologies (PST®, qPST™& TMT®), to major pharma, biotechnology
and diagnostic companies, to discover and exploit protein biomarkers.
Sensitizer® chemical mass tags have been developed separately as a series of
stand-alone reagents.

For further information please visit www.proteomics.com .

Enquiries:

Proteome Sciences plc

Dr. Ian Pike, Business Development Director

Email: [e-mail]

Christopher Pearce, Chief Executive Officer

Email: [e-mail]

Tel: [phone]

Public Relations for Proteome Sciences

IKON Associates

Adrian Shaw

Tel: [phone]

Mobile: [phone]

Email: [e-mail]