Notifiable Interest (TR-1)

Proteome Sciences PLC ("the Company")                     

                              Notifiable Interest                              

                                                                               

A form TR-1 containing the following information has been received by the
Company.

TR-1 notification of major interests in shares

1. Identity of the issuer or the underlying issuer of existing shares to which
voting rights are attached:

Proteome Sciences PLC

2. Reason for the notification

An acquisition or disposal of voting rights

3. Full name of person(s) subject to the notification obligation:

MF Global UK Limited

4. Full name of shareholder(s) (if different from 3):

N/A

5. Date of the transaction (and date on which the threshold is crossed or
reached if different):

16 November 2007

6. Date on which issuer notified:

19 November 2007

7. Threshold(s) that is/are crossed or reached:

6%

8. Notified details:

5.97%

A: Voting rights attached to shares

Class/type   Situation previous  Resulting situation after the triggering       
of shares    to Triggering       transaction                                    
             transaction                                                        
if possible                      Notification required under DTR transitional   
using ISIN                       provision 7                                    
CODE                                                                            
             Number of Number of Number of Number of voting   % of voting rights
             Shares    Voting    shares    rights                               
                       Rights                                                   
                                                                                
                                                                                
                                 Direct    Direct    Indirect Direct    Indirect
                                                                                
                                                                                
                                                                                
ISIN                                                                            
                                                                                
GB0003104196 9,140,174 9,140,174 7,844,703 7,844,703          7,844,703         
                                                                                

B: Financial Instruments

Resulting situation after the triggering transaction                           
                                                                               
                                                                               
                                                                               
Type of     Expiration Exercise/     Number of voting rights that may   % of   
financial   date       Conversion    be acquired if the instrument is   voting 
instrument             Period/ Date  exercised/ converted               rights 
                                                                               
                                                                               
                                                                               
N/A         N/A        N/A           N/A                                N/A    
                                                                               

Total (A+B)

Number of voting rights % of voting rights
                                          
                                          
                                          
                                          
                                          
       7,844,703              5.97%       
                                          

9. Chain of controlled undertakings through which the voting rights and/or the
financial instruments are effectively held, if applicable:

N/A

10. Name of the Proxy holder:

N/A

11. Number of voting rights proxy holder will cease to hold:

N/A

12. Date on which proxy holder will cease to hold voting rights:

N/A

13. Additional information:

N/A

14. Contact details:

[e-mail]